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SFA THERAPEUTICS
DRUG DEVELOPMENT PIPELINE

PRE-CLINICAL

PHASE 1

PHASE 2

PHASE 3

SFA 002

PSORIASIS

Additional Autoimmune Indications

SFA 009

ADJUNCTIVE THERAPY TO PANCREATIC CANCER 

SFA 001N

NASH/MASH (FIBROSIS), IND APPROVED

SFA 001

HEPATOCELLULAR CARCINOMA, ORPHAN 

SFA 003

BULLOUS PEMPHIGOID

SFA 004/5

UVEITIS, RELAPSE CML/AML

SFA 002

SFA 002

SFA-002 is a first-in-class oral immunomodulator that operates through multiple cellular pathways to treat autoimmune conditions, with an initial focus on mild-to-moderate chronic plaque psoriasis. Unlike current therapies that target single pathways through immunosuppression, SFA-002 works by simultaneously down-regulating multiple pro-inflammatory cytokines including TNF-α, IL-23, IL-10, IL-12, IL-17, and INF-γ, while modulating autoimmune responses. This oral compound has demonstrated promising efficacy in clinical trials, with an excellent safety profile and no observed adverse events. Currently in Phase 1b clinical development, SFA-002 represents a potential paradigm shift in autoimmune disease treatment, offering a multi-targeted approach that could provide patients with a safer, more accessible alternative to current injectable immunosuppressive therapies.

SFA 009

SFA 009

SFA-009 is a therapeutic candidate in development as an adjunct treatment for pancreatic cancer. Leveraging the company's proprietary SFA technology platform.  SFA-009 is designed to work in conjunction with existing pancreatic cancer treatments, potentially offering a new approach to improving outcomes in this challenging disease.

SFA 003

SFA 003

SFA-003, currently in late pre-clinical development, is a novel therapeutic candidate being developed for bullous pemphigoid, a rare autoimmune blistering skin disease.  Through its unique immunomodulatory mechanism targeting multiple cellular pathways, SFA-003 represents a potential new approach to treating this serious condition, which currently has limited therapeutic options.

SFA 001

SFA 001

SFA-001 is a novel therapeutic candidate in development for Hepatocellular Carcinoma (HCC), a type of liver cancer.  Leveraging the company's proprietary SFA technology platform, SFA-001 targets epigenetic pathways involved in liver cancer progression, potentially offering a new approach to treating this aggressive form of cancer.

SFA 001N

SFA 001N

SFA-001N is a novel therapeutic candidate in development for Metabolic Dysfunction-Associated Steatohepatitis (MASH), with a focus on liver fibrosis. Leveraging the company's proprietary SFA technology platform, SFA-001N targets cellular pathways involved in liver inflammation and fibrosis, potentially offering a new approach to treating this serious metabolic liver disease.

SFA 004/5

SFA 002

SFA-004/5 are novel therapeutic candidates in development for multiple indications including uveitis (an inflammatory eye condition) and relapsed Chronic Myeloid Leukemia/Acute Myeloid Leukemia (CML/AML). Building on positive clinical data in autoimmune conditions, SFA-004/5's offer new treatment approaches for both inflammatory eye disease and blood cancers.

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